MD, PhD – UJF & CHU de Grenoble

Email :
Téléphone :    +33 476 76 92 60
Fax : +33 476 76 92 62


Adresse géographique :     
Laboratoire HP2, INSERM 1042
Faculté de Médecine de Grenoble
Domaine de la Merci


Adresse postale :
Unité de Pharmacologie Clinique,
INSERM CIC3, Centre d’Investigation Clinique de Grenoble
C.H.U. de Grenoble, B.P. 217 ; 38043 Grenoble Cedex 09 – France


Jean-Luc Cracowski is MD, PhD, professor of Clinical Pharmacology at Grenoble University, France. He is in charge of the Clinical Pharmacology Unit at the INSERM Clinical Research Center in Grenoble, France. His main area of research is the pharmacology and physiology of human skin microcirculation. This includes the development of methods to assess skin microvascular function, their use in physiological and pathological conditions such as scleroderma and primary Raynaud’s phenomenon, and the development of new pharmacological approaches. In February 2014, His h-index was 25 and he was coauthor of 166 publications indexed in Medline.



- Pharmacology and physiology of skin microvascular function

Key-words : Microcirculation_Endothelium _ Laser Doppler _ Skin_Raynaud’s phenomenon_Systemic sclerosis



Jean-Luc Cracowski teaches Pharmacology at Grenoble Medical School, France.



Principaux articles (MAJ 02-2014):

Roustit M, Gaillard-Bigot F, Blaise S, Stanke-Labesque F, Cracowski C, Seinturier C, Jourdil JF, Imbert B, Carpentier PH, Cracowski JL. Cutaneous Iontophoresis of Treprostinil in Systemic Sclerosis: A Proof-of-Concept Study. Clin Pharmacol Ther. 2014 Jan 23. [Epub ahead ofprint] PubMed PMID: 24458011.

Cracowski JL, Chabot F, Labarère J, Faure P, Degano B, Schwebel C, Chaouat A, Reynaud-Gaubert M, Cracowski C, Sitbon O, Yaici A, Simonneau G, Humbert M. Proinflammatory cytokine levels are linked with death in pulmonary arterial hypertension. Eur Respir J. 2013 Nov 14. [Epub ahead of print]

Kotzki S, Roustit M, Arnaud C, Boutonnat J, Blaise S, Godin-Ribuot D,Cracowski JL. Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J Pharmacol Exp Ther. 2013 Sep;346(3):424-31.

Roustit M, Cracowski JL. Assessment of endothelial and neurovascular function in human skin microcirculation. Trends Pharmacol Sci. 2013 Jul;34(7):373-84.

Roustit M, Blaise S, Cracowski JL. Trials and tribulations of skin iontophoresis in therapeutics. Br J Clin Pharmacol. 2014 Jan;77(1):63-71.

Roustit M, Blaise S, Allanore Y, Carpentier PH, Caglayan E, Cracowski JL. Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud’s phenomenon: systematic review and meta-analysis of randomised trials. Ann Rheum Dis. 2013 Oct;72(10):1696-9.

Cracowski JL, Gaillard-Bigot F, Cracowski C, Sors C, Roustit M, Millet C. Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. J Appl Physiol (1985). 2013 Jan 15;114(2):245-51.

Cracowski JL, Labarère J, Renversez JC, Degano B, Chabot F, Humbert M. Plasma levels of high-density lipoprotein cholesterol are not associated with survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Jul 1;186(1): 107-8.

Roustit M, Hellmann M, Cracowski C, Blaise S, Cracowski JL. Sildenafil increases digital skin blood flow during all phases of local cooling in primary Raynaud’s phenomenon. Clin Pharmacol Ther. 2012 May;91(5):813-9.

Cracowski JL, Degano B, Chabot F, Labarère J, Schwedhelm E, Monneret D, Iuliano L, Schwebel C, Chaouat A, Reynaud-Gaubert M, Faure P, Maas R, Renversez JC, Cracowski C, Sitbon O, Yaïci A, Simonneau G, Humbert M. Independent association of urinary F2-isoprostanes with survival in pulmonary arterial hypertension. Chest. 2012 Oct;142(4):869-76.

Cracowski JL, Gaillard-Bigot F, Cracowski C, Roustit M, Millet C. Skin microdialysis coupled with laser speckle contrast imaging to assess microvascular reactivity. Microvasc Res. 2011 Nov;82(3):333-8.

Roustit M, Blaise S, Millet C, Cracowski JL. Impaired transient vasodilation and increased vasoconstriction to digital local cooling in primary Raynaud’s phenomenon. Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H324-30.

Blaise S, Roustit M, Millet C, Ribuot C, Boutonnat J, Cracowski JL. Cathodal iontophoresis of treprostinil and iloprost induces a sustained increase in cutaneous flux in rats. Br J Pharmacol. 2011 Feb;162(3):557-65.

Roustit M, Millet C, Blaise S, Dufournet B, Cracowski JL. Excellent reproducibility of laser speckle contrast imaging to assess skin microvascular reactivity. Microvasc Res. 2010 Dec;80(3):505-11

 Blaise S, Hellmann M, Roustit M, Isnard S, Cracowski JL. Oral sildenafil increases skin hyperaemia induced by iontophoresis of sodium nitroprusside in healthy volunteers. Br J Pharmacol. 2010 Jul;160(5):1128-34.

Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. Trends in Pharmacological Sciences. 2006 27: 503-508  (revue générale).

GR McCord, JL Cracowski , CT Minson. Prostanoids contribute to cutaneous active vasodilation in humans. Am J Physiol Regul Integr Comp Physiol. 2006; 291: R596-602.

J.L. Cracowski, T. Durand, G. Bessard. Isoprostanes as a biomarker of lipid peroxidation in humans : physiology, pharmacology and clinical implications. Trends in Pharmacological Sciences. 2002; 23 :360-366.

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